HIDS/HIPS has always been problematic because of chicken-and-egg rootkitability (ie a rooted box scanning itself is tantamount to worthless), also clean image scanning has been extremely inconvenient. It would make more sense to have an secure OS in ROM that runs at boot and at various times which bypasses the installed OS and drivers, and can scan firmwares, microcode on various buses and critical files. Basically, hardware TripWire, but with an authoritative signatures database. And certainly, UEFI Secure/Measured Boot is complementary for defense-in-depth.

Also, it would be helpful if PCIe, HDMI, USB, Thunderbolt, etc. drivers ask permission of the user before automatically connecting devices inserted into PCs... basically a peripheral "firewall." There are too many buses that are happy to give up the FSB and PCIe-side without authorization. Hell, it would be even better if buses used some sort of minimal-but-essential PKI and encryption.