The APA, AMA and other APA all seemed to find enough evidence to pass very clear resolutions calling for sex reassignment surgery to be considered a clear and effective medical intervention.

I know we are on Hacker News where everything must be done from first principles with whatever knowledge happens to be rolling around in the head of the person writing the comment, but this stuff is pretty settled folks.

Chemotherapy is a "clear and effective medical intervention". It doesn't mean that there are no meaningful repercussions or that it is right for everyone equally, unequivocally, and unconditionally.

The long-term implications of sexual reassignment surgery are far from settled.

Individuals undergoing chemotherapy also don't have their treatment constantly second-guessed by message board trolls.

I wouldn't be so sure about that. I can imagine a wide spectrum of comments from worried family members "Are you sure you want to put yourself through this? Maybe you should just let nature run it's course." to trolls intentionally prodding the insecurities of the cancer patient.