Indeed, due to the bangs, I know use DDG as my proxy to a lot of other search engines, like Wikipedia (!w/!wda/!w..) and Wiktionary (!wikt), and even obscure ones like Memory Alpha (!memoryalpha). Very handy indeed.
I rarely use region specific DDG, but when I do, I find it ok. With DDG I can manually enable/disable and switch the region, while Google guesses based on my IP - very annoying, given that I frequently use VPNs. (Of course, if you're logged in to Google, you can specify region/language/etc., but if you don't want to be tracked and delete their cookies or use the browser in private/porn/incognito mode, then it'll just assume that you are looking for Dutch things in the Netherlands, because that's where the VPN exit is...)
As for bangs, I love skipping clicks. Most of the time I know what I want and can use bangs accordingly. I'm guessing my most common tags are !a, !yt, !gh, !wiki, !wolf and then some game(s) specific bangs.
BTW, for wikipedia, !w is enough. Wolfram Alpha is !wa.
StartPage doesn't seem to be helpful at all. It doesn't let me select language and region separately. I need to select English UK and then it sets my region as UK. Also, it's very slow (at least for me)
Some say the DDG bangs are a solution. What do I win by doing that? It only made me resort to !g all the time, because the results were so bad.
Now I use https://www.startpage.com/ with region set to Swedish. It's practically a proxy for Google search, so it gives me the right results but sans the filter bubble experience (yes, I want the regional bubble). If you're a non US user, I can recommend it.