Or is there something about the actual power distribution, machines, cooling, etc?
Lots of potential for small optimizations that pay off on a large scale, but aren't feasible or worth the effort in smaller setups.
Second, they optimize physical cooling and power distribution thoroughly. Google has an overhead of just 12%. Here's a good overview of what they do: https://www.google.com/about/datacenters/efficiency/internal...
This needs a citation. One of the issues with AWS/etc is that they don't know the usage pattern of a customer that allocates a VM. A well managed vSphere system can be heavily oversubscribed with mostly idle VMs that don't need high performance.
With a function-as-a-service type computational model like Lambda, it becomes even more fine grained.
The only big examples of "high-latency" computing I can think of have been these volunteer distributed projects (BOINC, SETI), but maybe there's a commercial angle for that as well?