So, maybe it's not so much that we have stuff "figured out", as it is that we have mental models that, while they work well enough to make certain predictions, also constrain our thinking in terms of what phenomena are possible. The "EM drive" controversy is one example of this tension.
I'm not so sure of this. Have you heard of Edward Leedskalnin, or his "Perpetual Motion Holder"? The textbooks that I have discussing magnetism do not explain this effect, which you can see an example of here: https://www.youtube.com/watch?v=eWSAcMoxITw
If you can explain this effect with our "current theories", I would love to hear it!
There's another interesting effect where an electric charge can be pulled from that set-up. Lasersaber demonstrates that here: https://www.youtube.com/watch?v=S_ssUTRbRRs
I certainly can't explain it, and I don't think we have an adequate theory that does explain it (yet).
In other words, much of the problem we face in the current scientific age is due to the fact that our instruments are now electron microscopes and Hadron Colliders, instead of carefully made glass beads and simple mirrors.
It's similar to problem faced in software of managing increasing complexity. No silver bullets known of yet for all those problems, just chronic application of powerful minds to the problem. :)
For example within medicine when computer power and AI is advanced enough to help us much more connecting the dots between DNA, viruses, environment etc.
https://en.wikipedia.org/wiki/Superconducting_Super_Collider
for posterity: That collider can't get to the energy levels needed because it doesn't exist. It doesn't exist because it's construction was cancelled after the project was defunded. Where it to have finished construction, it would accelerate protons up to 20 TeV. The LHC reaches 6.5 TeV. All of that information is clearly stated in the link I posted and is completely uncontroversial.
Stop bullshitting.
Of our current energy/resolution paradigms
We know that ~20% of the universe is Dark Matter and that ~75% is Dark Energy. All we really know about Dark Matter is that it falls down and doesn't really interact with itself or anything else, really.
Dark Energy? Yeah, whatever it is, it pushes galaxies apart, that's about all we got.
There are a LOT of pretty easy discoveries to be made yet, but we just don't have the engineering to make them yet. The LHC was a marvel of engineering, but it can't even come close to the energy required to produce (theorized) Dark Matter particles. If you tried to make a bigger one, you'd need an LHC with a radius larger than the Earth's. That's not going to happen anytime soon, not by a long shot. We need another method than particle colliders, probably a very large space-based telescope to stare at black-holes with jets.
Biology is also rife with 'easy' things to do, but ones that we just don't have the tech for yet. Strangely, with all of the data that the Googs and the Zuck have, we have not seen a similar paradigm shift in psychology, criminology, or economics. At least in public literature.