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A comment on Combined overconsumption of fat and sugar leads to hypothalamic inflammation. Parent comment

Re:Combined overconsumption of fat and sugar leads to hypoth... by dtawfik1 on Tuesday September 05, 2017 @06:40PM (#15179679)
https://www.uaf.edu/files/olli/OLLI_15_chol_4_red.pdf Checkout slides 7 and 8. My simple understanding is that the sugar creates a particle that provokes an immune response. Cytokines attack the sugar-lipid particle that has been oxidized.
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Re:Combined overconsumption of fat and sugar leads to hypoth... by subcosmos on Tuesday September 05, 2017 @07:01PM (#15179803)
Glucose, in high concentration, reacts with proteins at arbitrary locations, effectively gluing them together. This is bad, so the immune system detects this (with a receptor called RAGE) and sends in reinforcements to eat the mess up.

https://en.wikipedia.org/wiki/RAGE_(receptor)

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