Yes. Upmarket brands are known to be plagued with various electrical and "feature" problems that don't bother other cars - the lone exception appears to be Lexus, which tends to rate about as high as Toyotas.

But Acuras tend to be less reliable than Hondas

Infinities tend to be less reliable than Nissans

and so on.

Basically, fewer moving parts means better reliability in general. In addition, lower level cars are much cheaper to repair for various reasons.

Want a car that will run forever on the cheap? You're probably driving it.