The technology will work with any kind of app. I know that some folks working on one of the bigger UI frameworks, Avalonia (https://github.com/AvaloniaUI/Avalonia) have toyed with it recently. One thing to keep in mind is that lots of these frameworks do dynamic, reflection-based data binding, which might be easily broken if the linker removes too much stuff. You can tinker with the settings of the linker to force it to preserve things that are actually necessary.

We currently have no GUI story for .NET Core. At the point that one gets added, yes, this will totally work.