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Re:Stanford scientist searches for answer to his son’s Chron... by chmike on Sunday August 13, 2017 @05:52AM (#15002278)
> antibiotics cause mitochondrial dysfunction (particularly bacteriocidal antibiotics)

You are very assertive, but this proves that you don't know what you are talking about. Antibiotics are all "bacteriocidal".

Beside, saying the mitochondries are responsible is like saying that the arm is responsible of an incapacity to move an arm. It could be due to a neurological, muscular or squeletical root cause. Mitochondries are the factories of ATP but there are many other factors in play.

A cause could be a lack of oxygen due to nocturnal apnea, etc. Lack of vitamins, lack of iron and/or red cells, etc. etc.

Re:Stanford scientist searches for answer to his son’s Chron... by evolve2017 on Sunday August 13, 2017 @09:22AM (#15002800)
I happen to share your skepticism about a mitochondrial origin for this syndrome, though I am not familiar with the research (would appreciate a review on the topic - I saw one linked earlier in the comments from BMC Genetics that seemed to conclude that mitochondria are not involved).

> You are very assertive, but this proves that you don't know what you are talking about. Antibiotics are all "bacteriocidal".

I also found this confusing when I first learned about it, but some antibiotics work by directly killing organisms (i.e., are bacteriocidal) whereas others simply block the ability of bacteria to grow (i.e., are bacteriostatic). [1]

There are a few clinical cases where one would avoid bacteriocidal antibiotics, as the internal contents of a bacterium could further worsen a patient's symptoms.

1. By no means an authoritative reference, just a cool demonstration of this concept: https://www.ncbi.nlm.nih.gov/pubmed/24284484