It is a multifaceted problem, but one aspect is having better answers to treating chronic pain, whether that be physical therapy, pharmaceuticals, psychotherapy, etc.

It very much is a mind-body thing because ultimately the brain gets signals from the body and it is the mind that determines if those signals are pain or just noise.

I think also situations of social inequality are feeding the opioid crisis. Black people in America were early adopters of trends such as the breakdown of the family and believing that "there ain't no making it" and now we are seeing that rural whites are experiencing these.