I'm a newbie to tmux but I use it with iTerm and I love it. I use my macbook for work but my dev code/servers are on a linux desktop. When I get into work I ssh to my linux box and type "tmux -CC attach" and my tabs all re-open like normal iTerm tabs and my subdivided terminal windows all restore to right where I left them. It's great for leaving all my watches/running code/tailing logs all open and in panes. It used to take me a couple of minutes to re-setup everything when I got into work but now I just run 1 command and I'm back to where I left off.

It's transparent, but doesn't seem to map 100%. Last time I used it a lot of stuff in my tmux config didn't work, like keyboard shortcuts.