That's kinda what I did. I wasn't head down on trying to build something, but I did write a novel while we were traveling, along with some freelance. We'd travel, moving from place to place frequently, then settle in somewhere with decent internet. We travelled through Peru and Chile, but lived in Buenos Aires for a month.

Travelled through much of SE Asia, but lived in Thailand for a couple months. India (travel) Spain (living) and so on.