Prefix notation is something you get used to; it's not as easy as infix for operations that use the same infix operators with the same meaning and priority in the domain (e.g., math) but real programming languages often use operators that aren't standard math operators and have precedence and/or associativity quirks with the operators they use which increase overhead. Prefix notation is basically everything-is-a-function, which I think is ultimately less overhead overall, though still more for simple math, than infix.

Indentation can help, too.