How a Reddit forum has become a lifeline to opioid addicts in the US

Re:How a Reddit forum has become a lifeline to opioid addict... by pyre on Wednesday July 19, 2017 @01:36PM (#14806137)

> Ibogaine causes long QT syndrome at therapeutic doses, apparently by blocking hERG potassium channels in the heart.

Yea. That doesn't necessarily sound good:

> Clinical studies of ibogaine to treat drug addiction began in the early 1990s, but concerns about cardiotoxicity led to termination of those studies. There is currently insufficient data to determine whether it is useful in treating addiction.

I'm not really sure this is some sort of miracle drug that the establishment just doesn't want us to know about.

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Re:How a Reddit forum has become a lifeline to opioid addict... by rhizome on Wednesday July 19, 2017 @02:09PM (#14806478)

I'm not really sure this is some sort of miracle drug that the establishment just doesn't want us to know about

The thing is, it doesn't matter if you're "sure" or not, because while it's on Schedule I there can be no federal funds used for research into whatever degree it may be a "miracle" (nirvana fallacy) drug. I hope we can agree that therapeutic substances have been derived from harmful ones.

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Re:How a Reddit forum has become a lifeline to opioid addict... by _acme on Wednesday July 19, 2017 @05:35PM (#14808186)

Can't research be done on other countries? Has research anywhere, of any kind, determined ibogaine to be useful in the treatment of addiction?

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Re:How a Reddit forum has become a lifeline to opioid addict... by rhizome on Wednesday July 19, 2017 @05:54PM (#14808331)

Here's a relatively recent roundup of the state of research: http://psychedelictimes.com/iboga/the-evidence-for-ibogaine-...

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Re:How a Reddit forum has become a lifeline to opioid addict... by _acme on Thursday July 20, 2017 @10:04AM (#14812507)

I'm not inclined to trust the Psychedelic Times to be particularly neutral on the topic or scientific.

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Re:How a Reddit forum has become a lifeline to opioid addict... by rhizome on Thursday July 20, 2017 @01:30PM (#14814567)

The yellow words are hyperlinks. Many of them go to outside websites.

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Re:How a Reddit forum has become a lifeline to opioid addict... by johncolanduoni on Wednesday July 19, 2017 @11:38PM (#14809874)

It can be done in the US with proper licensing, "just" if you get the funds from elsewhere. Not a small hurdle by any means, but it's not like you'll be blackballed (you can see plenty of studies of schedule 1 substances on PubMed, which is run by the US government).

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Re:How a Reddit forum has become a lifeline to opioid addict... by pyre on Thursday July 20, 2017 @01:53PM (#14814789)

I don't necessarily agree with it being Schedule I, but at the same time it's not "one weird trick" that the establishment doesn't want you to know about either. It's not something that's only waiting to be packaged up and sent to drug trials to start getting used (but is held back because "the man" thinks it will upset the status quo).

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Re:How a Reddit forum has become a lifeline to opioid addict... by bdamm on Wednesday July 19, 2017 @01:43PM (#14806226)

The drug is toxic in humans but I think it also means we can't do comparative trials on the mechanism in mice. There might be something to discover about the mechanism that could be brought by a different drug that doesn't have the cardiotoxicity.

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Re:How a Reddit forum has become a lifeline to opioid addict... by saint_fiasco on Wednesday July 19, 2017 @02:52PM (#14806833)

Is the cardiotoxicity worse than the side effects of the drugs they would replace?

I'm not sure there is an ethical way to find out.

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