And you know what? It's a valid strategy for those with the skill (or luck) to execute repeatedly. Sequoia earns their 3 and 30, or however much they charge.
All I'm saying is that when a company takes VC funding, the goal of the VCs can override the goals of earlier, individually less powerful investors (i.e. the angels). So while an early angel might be fine/thrilled with a 10x exit, the VC might not be because their risk/reward profile differs from the angel. Thus, when investing in companies intending to seek venture capital, one must be aware of the high payout, low odds bet into which they are entering.
Of course, there are ways to mitigate this like secondary market liquidity or institutional investors buying stock from earlier angels as part of a round. But the point still stands.
And also some of the individuals (angels) investing alongside the above institutions.