So sorry to hear this. It sounds like you guys are doing the right research. Being in a similar boat, I think that the checkpoint inhibitors look very promising. I try to keep up with the field as best I can. The hard part is you have to find an appropriate clinical trial for whatever you and your doctor think is best... Also, just as an FYI, the NCI is starting up a new precision medicine trial (NCI-MATCH) to target specific pathways instead of tumors... but I'm more of the opinion you have to do combination chemotherapy and modalities unless the drug is super effective. But then again I'm not an oncologist or a doctor.