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A comment on Response to “Unexpected mutations after CRISPR-Cas9 editing in vivo”. Parent comment

Re:Response to “Unexpected mutations after CRISPR-Cas9 editi... by danieltillett on Thursday July 06, 2017 @06:08AM (#14709241)
The real problem is not p-hacking (this is bad), but the lack of replication. All problems in science can be solved with replication, but almost nobody does it because it is near impossible to get a replication study published in a worthwhile journal.

No other problem in science is more important to solve.

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Re:Response to “Unexpected mutations after CRISPR-Cas9 editi... by thwd on Thursday July 06, 2017 @06:17AM (#14709272)
Just like peer review is a necessary step for a study to be taken seriously, replication studies should be regarded as the direct next step. There needs to be incentive to reproduce the experiment.
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Re:Response to “Unexpected mutations after CRISPR-Cas9 editi... by danieltillett on Thursday July 06, 2017 @06:27AM (#14709311)
Replication is far more important than peer review. I would rather a 1/10th the number of "advances" published if I could rely on the results to be true, and even more importantly, robust.

When I used to run a lab we used to only consider results that had been replicated in at least two unconnected labs. Everything else was just a waste of time (on average).

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