Response to “Unexpected mutations after CRISPR-Cas9 editing in vivo”

Re:Response to “Unexpected mutations after CRISPR-Cas9 editi... by semi-extrinsic on Thursday July 06, 2017 @02:42AM (#14708574)

Even more interesting is the proposal I've seen where you submit the intro, theory and methods section for review at a journal before you do the expeiments. Once what you're planning to do is deemed good and interesting by the reviewers, you get the go-ahead, and the journal will publish your results no matter what they are. Not only does it prevent p-hacking, it also removes bias against negative results.

FWIW, anti-p-hacking measures are already implemented for clinical trials; they have to register expected outcomes at the beginning.

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Re:Response to “Unexpected mutations after CRISPR-Cas9 editi... by jacquesm on Thursday July 06, 2017 @04:07AM (#14708848)

Journals should not be given the power to implicitly decide what research gets done and conversely they will never accept to be forced to publish all results because of the vast amount of research that goes nowhere.

The whole value for a journal is to be able to select once the results are known because that's how you build prestige.

All you are doing in effect is to lay out a good case why journals should and probably will simply die because this level of transparency would be a great thing to have but is incompatible with the publishers model.

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Re:Response to “Unexpected mutations after CRISPR-Cas9 editi... by hackeyed on Thursday July 06, 2017 @07:34AM (#14709571)

Many of the journals currently publishing these kind of Registered Reports only publish special issues, which might help with your concern about journals being given control over what work is done in a field, though it also limits how much of the literature can benefit from the new approach.

Another way of thinking about a journal's incentives is that, by moving the primary peer-review stage before a study has actually been conducted, you greatly expand the number of studies that a journal will interact with, which may provide a larger and more valuable role for entities like journals in world where actual publishing is a trivial matter.

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Re:Response to “Unexpected mutations after CRISPR-Cas9 editi... by hackeyed on Thursday July 06, 2017 @07:25AM (#14709545)

The format is called "Registered Reports" and a current list of journals that use it is available at https://cos.io/rr/

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