VanillaJS, jQuery, and Ember will be very far from VB in terms of simplicity. There really is nothing quite like VB for web development right now. It's strange/interesting that such a thing hasn't been created yet (or hasn't gained any traction).

I think React comes close in the sense that the code you write to create the components can map very closely to divs on an HTML page. There's no visual drag/drop editor or anything, but with Create React App, you can make changes to the code and see the browser refresh every time you save.

Have a look at the official React tutorial too: https://facebook.github.io/react/tutorial/tutorial.html

EDIT: now that I've bothered to Google it, here's at least one project that looks like a VB-style builder using React: https://github.com/ipselon/structor