I also block the Hot Network Questions on Stack Exchange sites while at work – though not when using my home profile. As a Firefox user, I simply added the following lines to my `userContent.css`:

    @-moz-document
        domain("stackoverflow.com"),
        domain("superuser.com"),
        domain("serverfault.com"),
        domain("askubuntu.com"),
        domain("stackexchange.com")
    {
        #hot-network-questions {
            display: none;
        }
    }