The only reason I have had lately to get annoyed at Python is when one of the guys I'm working with on a project was using an editor where the tabspacing wasn't set correctly. That meant anything that he changed/added led to the script not working. Even though this was an easy change (=G in vim), it's still annoying to think that such a minor issue would completely kill the script.

Of course I prefer Ruby, but that's a whole other can of worms :)