In the 2D animation industry it's mostly irrelevant since we are animating on ones, twos, and fours (every single, second, or fourth frame at 24fps) depending on what is happening in the shot.

There is also not nearly as much tweening as you might expect. Sometimes animating on ones just cannot accurately give you the same effect as letting a persons brain fill in the missing info. Which is why watching The Hobbit in 48fps pulled me out of the movie at some points; I appreciated the extra clarity, but there were details that would have otherwise just been a blur that became distracting.