Hello World is only your first test case to get all the tooling up and running. The real work starts after Hello World and is expected to become more complex. Within minutes you will grow tired of manually running transpilers, minifiers, tests, adding each new js module to index.html etc. You will want to automate all of this. At least this is my experience every time I start a new project.
Pick tools which you are comfortable with and which solve problems you actually have. Otherwise, you'll be left complaining about some vague "community" that is "forcing" you to adopt the "modern standard", even though there's nothing "standard" about the apps this "community" develops as a whole.