Rigetti's quantum computers can be operated by way of the means discussed by other commenters (toothpicks and tweezers at the oscilloscope), or can be loaded with a quantum instruction code called Quil [0], which can be written with Python using pyQuil [1,2]. The former is preferred by physicists doing physics experiments, and the latter by software engineers and application developers.

[0] https://arxiv.org/pdf/1608.03355.pdf

[1] http://forest.rigetti.com/

[2] https://github.com/rigetticomputing/pyQuil