I have the same setup. It's as easy to get going as others have said. For the comskip portion if you are on Windows most use MCEBuddy, this video explains it pretty well: https://www.youtube.com/watch?v=t03CnX3H7AA

My plex server is Mac, so I used this guide: https://forums.plex.tv/discussion/comment/1273228#Comment_12...