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Re:Intel Announces Skylake-X: Bringing 18-Core HCC Silicon t... by mamon on Tuesday May 30, 2017 @06:30AM (#14444229)
It limits what peripherials can be attached. For instance, single graphic card uses 16 PCIe lanes, so having only 28 lines supported by processor makes it impossible to have two GPUs in SLI mode (ok, not impossible, because motherboard chipset can add some lanes, but performance will suffer)

NVMe SSD drives also use some lanes (typicaly 4), and you might want two of them in RAID.

Re:Intel Announces Skylake-X: Bringing 18-Core HCC Silicon t... by theandrewbailey on Tuesday May 30, 2017 @09:24AM (#14445139)
Numerous tests show that performance is not meaningfully impacted by running two GPUs on 8x PCIe lanes vs 16x lanes, especially when using PCIe 3.0.
Re:Intel Announces Skylake-X: Bringing 18-Core HCC Silicon t... by Sephr on Tuesday May 30, 2017 @06:38PM (#14449130)
It's a huge difference for minimum frame times at 4K if you intend on getting a smooth 120fps.
Re:Intel Announces Skylake-X: Bringing 18-Core HCC Silicon t... by seanp2k2 on Tuesday May 30, 2017 @01:49PM (#14447074)
with current-gen GPUs

That could also change over the next few years.

Re:Intel Announces Skylake-X: Bringing 18-Core HCC Silicon t... by vonmoltke on Tuesday May 30, 2017 @07:02PM (#14449278)
What are the chances you will still be running the CPU and motherboard you buy today in a few years?
Re:Intel Announces Skylake-X: Bringing 18-Core HCC Silicon t... by Zardoz84 on Tuesday May 30, 2017 @10:13AM (#14445484)
So, if you not have plans of putting a NVM SSD plus two GPUs on SLI configuration, with 16 PCIe lanes will be enough.