I've Psoriasis and Psoriatic Arthritis in my late 20's. Anecdotally I can say I never believed the hype about the effect of marijuana use on inflammation. After going straight in the past 30 days (job hunting), I can say I thoroughly miss not itching over my entire body 24/7 and not feeling fire in my hands. To quantify I have decided to only pursue jobs in legalized jurisdictions.