Jepsen test results basically show that latency caused by replica distance won't screw your data. On the other hand, clock drift can stop your system, or even potentially corrupt your data, depending on how fast such incident can be detected/handled and what is your workload/what you are doing.

Yes, it works. Your latency will just be correspondingly higher (due to the speed of light). We are constantly testing a cross-region (i.e. US-East and US-West) cluster and have periodically run tests on cross-continent clusters (US to Asia-Pacific).

In these cases you can help the cluster out by following some of the advice on the "Recommended Production Settings" page (https://www.cockroachlabs.com/docs/recommended-production-se...) around specifying which `--locality` each node is in.