No, but they can investigate where there is the possibility of conspiracies. Basically everything Uber does involves the flow of data across state lines and the feds can investigate otherwise state crimes that cross multiple states. This is what Uber needs to really worry about:

"If two or more persons conspire either to commit any offense against the United States, or to defraud the United States, or any agency thereof in any manner or for any purpose, and one or more of such persons do any act to effect the object of the conspiracy, each shall be fined under this title or imprisoned not more than five years, or both."

https://www.law.cornell.edu/uscode/text/18/371