I've been using Typescript for a while and have used a lot of frameworks for it, and some lack of frameworks (one of my earliest Typescript projects was a large conversion of an enterprise JS code base consisting of a mixture of JQuery 1.x, Backbone, and Knockout code). These days I've got one big project in Aurelia (which I'm not entirely thrilled with sometimes) and another in Cycle.js (which is quite cool and I'm using TSX there even).