Like the other reply said, amphetamines give you the nervous, high focus, zeroed-in feeling. Great for cranking out a ton of code if you write a to-do list beforehand, otherwise I get lost in trivial, pixel-perfect design stuff. An LSD microdose is a much more relaxed high, tons of mental energy but less focused (which is a good thing, compared to amphetamines). Especially for creative work or higher-level/algorithmic programming.