I've done it 30 days in a row once. Tolerance is really quite negligible at these doses. However you do definitely notice full +50ug trips between for about 1-2 days afterwards.

Also, tolerance is maybe the wrong word as it suggests that all effects are diminished. With psychedelics, pretty much all of them except DMT when microdosing, it seems more like this for continous microdosing without days off:

Day 3-4: Loss of the psychedelic "touch" in thought and perception, including associated creativity and easier ability to psychedelic thinking, now feels more like a stimulant without associated amphetamine bodyload

Day 5-6: Slight loss of clarity

Day 8-9: Further loss of clarity and beginning loss of energy and stimulation

Day 12-13: Sober state becomes indistinguishable from microdose - true tolerance sets in

> negative bodyload

Can you expand on that? Thanks. (:

Amphetamine bodyload? Shotgun 7-8 coffees and you'll know ;)

Nervous energy would be a better word, I guess.

Back in my carefree youth, I often took LSD multiple times a week. I never noticed any sort of "tolerance"... tripping was tripping. Of course, not microdosing, and not daily, but it doesn't feel like a "tolerance" drug, really, the way, say, opiates are a tolerance drug.