I think it's helpful to distinguish between the more recreational, or life-boosting user, and those who might use it to alleviate conditions that would normally warrant psychiatric medications. For the former, you're definitely messing with a stable mind.

For the latter, this is totally a new frontier. This mechanism at least on the surface seems to mimic SSRIs, so presumably tuned properly could be a more holistic replacement, considering LSD's ability to allow people of all conditions to also do some soul searching on a personal level. Similar to how the recommended, accepted treatment is medication + therapy.