I don't see why not! The release itself uses Love2D just because that's easy to run on most machines, but the gameboy module (in the /gameboy folder) has no non-Lua dependencies or code. Its "bit" library or equivalent should be available in most environments.

Essentially you could use import the /gameboy module, write your own shell as a WoW extension, toss the graphics onscreen somewhere, and optionally deal with audio by setting the appropriate callback.