Audio user here too. I just updated to 10.12.4 yesterday on a test install and it went without a hitch, but only because I checked Tonymac and updated Clover beforehand, which I wouldn't have done otherwise. And I'm on a old GTX 650 Ti that doesn't need the Web Drivers. Meanwhile my main 10.9.5 work install keeps gloriously chugging along.
I would agree with the overall sentiment though and add that even on a legitimate Mac it's usually a good idea to hold back a bit on updating. I work with audio a lot and it's common for audio units (and Pro Tools if you use that) to break initially.