Case(s) in point: the FCC, FDA, minimum wage laws, Federal involvement in education.
None of those is Constitutional without some laughable legal gymnastics around inter-State commerce, and yet very few people have been complaining about their existence over the years.
As a non-American observer, the whole system seems reminiscent of ancient Rome at the point where it had become an Empire but was still pretending it was a Republic.
Take Obamacare as an example. Leaving aside the issue of whether socialised healthcare is a good idea, Obama had to circumvent the law by instructing the IRS to collect revenues via an executive order.
Is that really a precedent that should have been set? Even socialists should have been a little uneasy at the disregard for the Constitution there, but instead, the ends won out over the means, and it went ahead.