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Re:Nubsio GPIO API – A Windows USB interface for controlling... by tyingq on Monday April 03, 2017 @11:52AM (#14023757)
Adafruit just put the chip on a breakout board. There's .net support for it.

A couple of sources:

http://www.ftdichip.com/Support/SoftwareExamples/MPSSE/FTCSP...

https://github.com/zhelnio/MPSSELight

Re:Nubsio GPIO API – A Windows USB interface for controlling... by madeintheusb on Wednesday April 05, 2017 @03:59PM (#14045066)
You are right there is .NET support, I used it the SPI library. I think there one library for I2C and one for SPI. I settled on the FTDI ft4222 which is somehow easier to program and can only do SPI and I2C (no IO, no UART). The FT232H could be faster in SPI.