The thing to understand about nature is that it is made up of complex systems that have evolved into finely balanced equilibria. Our reductionist science only works well in linear systems where variables are cleanly separable, which complex systems by definition are not. Thus tinkering with nature under the assumption that it is a linear system is likely to have lots of unintended consequences. That is why science's track record in promoting health is so abysmal, and our agriculture is completely unsustainable.

The only way to really evolve a complex system is to make a lot of small gradual changes, constantly course correcting as you go.