The IDE support I yearn for is the really nice autocomplete support you see in tools designed specifically for TS. Last I used it, it was very flimsy in Sublime and Atom--very little in the way of helpful suggestions. Perhaps that's been improved, which I would welcome.

The loaders I use in webpack are mostly around asset loading. Style loaders, integration with other languages (coffeescript...ugh) for some weird legacy code, etc.