However, we do think there's a good chance of getting higher returns. Givewell recommendations skew towards what makes sense for an average, individual donor with a particular risk profile. By having access to a larger pool of funds, you could seed new high-expected-value charities that wouldn't necessarily make it onto Givewell's recommendation list, but are nonetheless potentially high impact (examples of recent things in this space — New Incentives, Charity Science Health etc).

    single tax receipt (donating to one org instead of 3-4)

You can donate to GiveWell for distribution to their to charities, and you can either choose the breakdown or ask them to allocate it as they think best.

With our Global Health and Development Fund, we hope to also make small, seed grants to promising new initiatives, to help them build evidence to support their program, or to replicate a promising intervention in a new geographic region, to figure out if the program can scale. Many of these donation opportunities are small, and individual donors won't necessarily hear about them. With Elie managing this fund, we hope to be able to quickly fund promising new projects, so they spend less time on PR and fundraising, and more time doing good work.