It is a slow start, but jobs have already started shifting from the UK to other EU member countries (particularly for companies based elsewhere in the EU). We'll also likely see reductions in exports as UK goods cost more for other countries to import than competitors elsewhere, and UK imports from the EU go up in price (due to tariffs) and elsewhere (due to weaker trade agreements).
We also may see "brain drain" as students and highly qualified pros go to countries like Germany, France, Sweden, and Ireland where they can gain/maintain full EU travel/rights/benefits. Gaining citizenship in England & Wales is simply going to be seen as less useful than in e.g. Germany.
Overall we're just on the leading edge of how bad Brexit is going to be, the loss of the GBP's value is the market trying to "build in" projected future weakness. It could take England & Wales thirty years to fully recover from Brexit.