the only real problem I had with setup was sound: emulated sound had buffering issues, as did USB
I would suggest buying a cheap soundcard, giving it to the VM and running a cable between its output and line-in on your host (which hopefully has hardware support, so the sound doesn't have to be touched by the CPU by the host system)
be careful though, the hardware selection relies on trial and error quite a bit, devices have to support things like MSI interrupts, the board has to have proper ACS support, bios support has to be there, and so on
even picking things like graphics cards is a problem, some AMD cards support hot-plugging properly, others of the same generation don't
(and just because it's on the datasheet doesn't mean it works in practice :/)
With regards to usability and customizability, IMHO Unity seems to get worse with each release, so eg. now it no longer supports screenlets, and even the "Unity Tweak tool" no longer seems to work for several useful "tweaks".
But, I just don't get why do people assume it's either "plain" Unity or back to Windows. Have you ever tried Kubuntu? Or MATE, Cinnamon, Xfce flavours? I personally find KDE Plasma 5 the best DE ever, period - that is, once you invest those few minutes customizing it / fixing its few oddities here and there. Why don't you try it out?
For me, my biggest beef with Unity was a death from a thousand papercuts. EG: i wanted to open a file in a program and had to navigate to the location, and couldn't just copy the folder path as I did on Windows. Or when I wanted to Alt-Tab between two windows of the same program, I couldn't do it with Alt-Tab. To remove it, the forums told me to launch a program which then for some reason didn't open when I double clicked on it. And then I realized that Sublime Text was not longer called Sublime Text but Ubuntu somehow renamed it to the last file opened as admin, which was aparently a well known bug with Unity.
Then I read that the next version of Unity is a rewrite from scratch, with usually means many new fun bugs, and just said 'forget it'.
Now, is any of these DE simple to use and with well-thought defaults? I can try out a few ones (after all I will do a clean wipe of my desktop) but sadly don't have the time to test more than a few DEs.