PyQt has a whole other project, called sip, in service to it. If I understand it correctly, sip generates the bindings semi-automatically with a lot of special cases for Qt. Compared to the other set of Python C++ library bindings I've used (Vtk), they're magnificent.

Any tips you can give as far as starting to learn VTK, especially its Python bindings?

My experience is with maintaining somebody else's code, so I learned by cutting myself on its sharp edges. My advice is to avoid if possible. Unlike Qt, you can't subclass Vtk objects in Python. Which is a huge pain, because the Vtk design is heavily object-oriented. The autogenerated documentation is pretty unhelpful. It looks like this: http://www.vtk.org/doc/nightly/html/classvtkSliderWidget.htm.... Compare that with the magnificent Qt documentation: http://doc.qt.io/qt-5/qslider.html, and you'll see why I prefer working with Qt.