In April 2016 a German-registered Challenger business jet flew east-west across the UK and was just about to enter Irish airspace when the RAF Typhoons reached it.
Then in October the same happened with a Volaris A320 that managed to fly most of the south-north extent of the UK before being intercepted, again just before leaving UK airspace.
In both cases if there had been any malicious intent then it could easily have been executed over major cities. In fact I watched that A320 fly over my town... The problem in the UK is that the main fighter bases are on the east coast, to combat the Soviet hordes that never arrived. So basically everything is a supersonic tail-chase for the interceptors unless it's coming from the Benelux countries. The RAF really needs to redispose its units for dealing with the new 'threat' but there's simply no money to do so.
And it looks like the 2 planes came from different bases.
If you look at this map of German airforce bases, one of the biggest is in Cologne (Köln-Wahn), so its no surprise that they were this quick
http://www.luftwaffe.de/portal/a/luftwaffe/start/team/stan/!...
Try flying over NYC out of contact for 15min and lets see how it goes.
When you file your travel plans you'll have to check in with different ATCs at different points, you are also likely to be contacted by ATCs depending on the flight plan, conditions and various other factors during the flight.
If you do not check in on schedule e.g. when there is a handover of ATCs or you do not respond to ATCs that trying to make contact with you, there will be a flag and an alert will be likely sent. If this goes on for minutes then they'll assume something was wrong and follow their procedure to make contact and investigate which might involve scrambling jets to make visual contact.
It's not like pilots can be too busy to respond to ATCs yes they might delay a response if they are in a middle of a sentence with a member of the air crew but that's a 5 seconds delay. Even a 1 minute delay would be flagged and you'll likely to be asked why you haven't responded or made contact on time.
I know there are some guidelines for the Luftwaffe like "a fighter needs to be able to get to any point in german airspace within 15 minutes" or so, but that all sounds VERY fast.
Edit: Formatting