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Re:Ask Hackers: How to become the best JavaScript programmer... by jeresig on Thursday March 13, 2008 @01:37PM (#136102)
I should say that /any/ framework is not intended for performance-critical code. A framework is designed to be an abstraction - abstractions implicitly remove you from what you're trying to do, causing a performance hit of some sort. If performance is your #1 priority then you should be writing everything from scratch.

Now if development time is a greater priority over performance then I think the choice is pretty obvious.

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