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Re:A first look at WebAssembly performance by Veedrac on Thursday February 09, 2017 @07:14AM (#13606372)
Javascript engines are fairly speedy compared to CPython; not only are they industrial-grade JITs (as opposed to CPython being a naive interpreter), but JS is an easier language to optimize. Further, WebAssembly has overhead.

5-7x difference seems reasonable to me.

Re:A first look at WebAssembly performance by fulafel on Friday February 10, 2017 @12:42AM (#13613481)
The CPython interpreter has actually seen a lot of performance work, they've long been pushing the boundaries of interpreter optimizations that you can do portably & compatibly. I wouldn't describe it as a "naive interpreter".