Ugly and simple truth: no. In real life, in a customer centric approach, you can choose to ignore even 50% of your users anyway, from a marketing pov, if you decide those are not the users you care about (hint: you care about those willing to pay way way more - like when you make an overpriced iOS app but completely ignore Android to give another example). Why care about... less than 1% of users, when you already chose to ignore an even larger percent in your other approaches? Fair? No. Makes sense? Yes.

Expose all data trough a clean and documented API. If screenreader accessibility matters, someone will eventually pay you to develop an alternate interface using same API, or an open-source will be developed at some point...

Solution to accessibility problems is usually: (1) expose your data though an API, (2) wait to be paid to develop a truly accessible alternate "light" UI (if it ever happens), but don't cripple the "main ui" (well, actually more like "have it like the customer wants it" ;) heavy animations and fx are "crippling" in my personal view too...).