As a user of AdBlock, unless it's a site I desperately need to function (there aren't very many of these), having it be broken with AdBlock turned on clues me in that something shady is going on. I'm more likely to simply leave and never come back.

Note here that I'm not against certain kinds of advertising, and I'm all for subscription models and donation incentives and a great many other ways to fund sites. But third party advertising networks have forever lost my trust, and I simply won't tolerate the security risk nor the annoyance any longer. Your site is welcome to require me to disable AdBlock, and that's fine. I don't need to read your posts that badly anyway.