Linus Pauling coined the term because the adverse effects are almost next to non existent even in very huge doses compared to almost all of allopathic medicines (except nootropics). I am taking bunch of nutrients in megadozes for last 7 years, some in what others consider extrimes like A (10-100K IU),D(5-50k IU),C(5-100g),B(50-500mg) etc, some occasiionaly and some every day like C. I never had any side effect worth mentioning. Its VERY hard to poison yourself with vitamins and minerals, you really have to take ludicrous amounts. Iron is probably the only one that man do not have to supplement because it accumulates without blood donations.

I typically scan medical journals for adverse effects before experimenting and devise the dose based on what was used in studies and depending on what I try to achieve.

The only thing that got me was 1+ mg of iodine as Lugols solution, but it seems that I am somewhat alergic to it or it starts up some strange metabolic process in me. That does is very safe even in toddlers.

Talking about copper, I wonder why would anyone supplement it - its certain that copper water pipes continually leak copper in the tap water. Unless you drink water from the bottle, chances are probably low that you have copper deficiency. There are many other more probable things that affect lypolisys like Vitamin C, D, Chromium, Choline, Carnitnine, Iodine, Mg, Retynol, K2, CoQ10. I would bet on any of them prior to copper. For each there is known biochemical pathway that influences lipolysis and all people are typically deficient in almost all of them.

If your micronutrient status is adequate you have no effect. Since its way more expensive or impossible to do status tests then to actually buy the nutrient and give it a chance, I opt for the latter.

The dose also depends on technology used and other potential bioactivators. LET technology, for example is very effective. Pipperine will make a dose lower of anything in general case. Synergy counts too.