How to Avoid a Post-Antibiotic World

Re:How to Avoid a Post-Antibiotic World by yborg on Sunday January 22, 2017 @01:23PM (#13456365)

It would appear that the science is still not decided on this. If the resistance is carried on plasmids, it may disappear relatively rapidly from a population if the selection pressure for it is removed:

https://link.springer.com/article/10.1007/BF02017169 http://bmcevolbiol.biomedcentral.com/articles/10.1186/1471-2... https://www.ncbi.nlm.nih.gov/pubmed/1944394

There are other studies indicating that in the wild plasmid loss is a slow process:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966108/

And resistance expressed by genes that become part of the core genome of a bacterial species would presumably be much harder to lose.

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Re:How to Avoid a Post-Antibiotic World by majkinetor on Sunday January 22, 2017 @06:56PM (#13458520)

Thanks for the links. This stands out:

>. The presence of ascorbate induced a 50-75% decrease in minimal inhibitory concentrations of different antibiotics for resistant strains. When ascorbate is added, formerly subinhibitory concentrations of penicillin or tetracycline have an increased inhibitory effect on resistant strains and even induced the death of 25-93% of the initial population. These results suggest that ascorbate can induce the loss of several plasmids of S. aureus, and that the levels of antibiotic resistance are also affected by the presence of this compound.

Vitamin C saved the day again ! This level requires intervenous treatment tho, something considered frindge science at this moment for lame reasons.

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